منابع مشابه
Microsomal oxidative damage promoted by acetaminophen metabolism.
Adverse reactions of acetaminophen have been associated to oxidative stress, which may be elicited by reactive oxygen species (ROS) and/or production of the metabolite NAPQI. Both phenomena would arise through the activity of liver cytochrome P450 (CYP450) system, but their contribution to this oxidative stress is yet to be clarified. A NADPH oxidase activity has been proposed in rat liver micr...
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Role of Bacillus subtilis Error Prevention Oxidized Guanine System (GO) in 1 Counteracting Hexavalent Chromium-Promoted-Oxidative DNA Damage 2 3 4 Fernando Santos-Escobar, J. Félix Gutiérrez-Corona and Mario Pedraza-Reyes 5 6 7 Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, 8 P.O. Box 187, Guanajuato, 36050, Gto. México. 9 10 11 12 13 Running Title: Rol...
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The generation of reactive oxygen species has a pivotal role in both acute and chronic glomerular injuries in patients with lupus nephritis. As the transcription factor Nrf2 is a major regulator of the antioxidant response and is a primary cellular defense mechanism, we sought to determine a role of Nrf2 in the progression of lupus nephritis. Pathological analyses of renal biopsies from patient...
متن کاملMechanisms of tissue injury in lupus nephritis
Disease heterogeneity remains a major challenge for the understanding of systemic lupus erythematosus (SLE). Recent work has revealed the important role of nonimmune factors in the development of end-organ damage involvement, shifting the current paradigm that views SLE as a disease inflicted by a disturbed immune system on passive target organs. Here, we discuss the pathogenesis of lupus nephr...
متن کاملEffect of Troxerutin on Oxidative Stress Induced by Sciatic Nerve Ischemia-reperfusion Injury in Rats
Background:Troxerutin has antioxidant and anti-inflammatory properties and in this study, its antioxidant effect on the reduction of oxidative stress induced by ischemia-reperfusion sciatic nerve injury was investigated. Methods:In this study, 64 male rats were randomly divided into 8 groups as follows: 1- IR2: ischemia (3 hours) and reperfusion (2 days), 2- T...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2001
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2001.00975.x